From 2010 to 2011, Ana de Armas played Nerea in the TV series Hispania, la leyenda. In 2006, she made her acting debut in the film Virgin Rose.
De Armas starred in four films in 2020, including "The Informer," "The Night Clerk," "Sergio," and "Wasp Network." For all four roles, she earned favourable feedback.
Ana de Armas relocated to Los Angeles in 2014 following a five-year marriage to Marc Clotet.
Blade Runner 2049 earned her a Saturn Award nomination for Best Supporting Actress in 2018.